Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features
Identifieur interne : 001C94 ( Main/Exploration ); précédent : 001C93; suivant : 001C95Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features
Auteurs : Jian Lei [Allemagne] ; Jeroen R. Mesters [Allemagne] ; Christian Drosten [Allemagne] ; Stefan Anemüller [Allemagne] ; Qingjun Ma [Allemagne] ; Rolf Hilgenfeld [Allemagne]Source :
- Antiviral Research [ 0166-3542 ] ; 2014.
Descripteurs français
- KwdFr :
- Alignement de séquences, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Cristallographie aux rayons X, Domaine catalytique, Données de séquences moléculaires, Modèles moléculaires, Papaïne (), Papaïne (antagonistes et inhibiteurs), Papaïne (génétique), Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Protéines virales (génétique), Structure tertiaire des protéines, Séquence d'acides aminés.
- MESH :
- antagonistes et inhibiteurs : Papaïne, Protéines virales.
- enzymologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Papaïne, Protéines virales.
- Alignement de séquences, Coronavirus du syndrome respiratoire du Moyen-Orient, Cristallographie aux rayons X, Domaine catalytique, Données de séquences moléculaires, Modèles moléculaires, Papaïne, Protéines virales, Structure tertiaire des protéines, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Catalytic Domain, Crystallography, X-Ray, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (enzymology), Middle East Respiratory Syndrome Coronavirus (genetics), Models, Molecular, Molecular Sequence Data, Papain (antagonists & inhibitors), Papain (chemistry), Papain (genetics), Protein Structure, Tertiary, Sequence Alignment, Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Viral Proteins (genetics).
- MESH :
- chemical , antagonists & inhibitors : Papain, Viral Proteins.
- chemistry : Middle East Respiratory Syndrome Coronavirus, Papain, Viral Proteins.
- enzymology : Middle East Respiratory Syndrome Coronavirus.
- genetics : Middle East Respiratory Syndrome Coronavirus, Papain, Viral Proteins.
- Amino Acid Sequence, Catalytic Domain, Crystallography, X-Ray, Models, Molecular, Molecular Sequence Data, Protein Structure, Tertiary, Sequence Alignment.
Abstract
The 3D structure of the MERS-CoV papain-like protease (PLpro) has been determined. The enzyme has a deficient oxyanion hole and unique S3 as well as S5 subsites. Restoring the oxyanion hole through mutagenesis enhances the enzyme kinetics. The unique features of the enzyme will allow design of MERS-specific antivirals.
Url:
DOI: 10.1016/j.antiviral.2014.06.011
PubMed: 24992731
PubMed Central: 7113875
Affiliations:
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Mesters</name><affiliation wicri:level="1"><nlm:aff id="af005">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF)</wicri:regionArea></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:aff id="af010">Institute of Virology, University of Bonn Medical School, 53127 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Bonn Medical School, 53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF)</wicri:regionArea></affiliation></author><author><name sortKey="Anemuller, Stefan" sort="Anemuller, Stefan" uniqKey="Anemuller S" first="Stefan" last="Anemüller">Stefan Anemüller</name><affiliation wicri:level="1"><nlm:aff id="af005">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF)</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Qingjun" sort="Ma, Qingjun" uniqKey="Ma Q" first="Qingjun" last="Ma">Qingjun Ma</name><affiliation wicri:level="1"><nlm:aff id="af005">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF)</wicri:regionArea></affiliation></author><author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><affiliation wicri:level="1"><nlm:aff id="af005">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF)</wicri:regionArea></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Catalytic Domain</term><term>Crystallography, X-Ray</term><term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term><term>Middle East Respiratory Syndrome Coronavirus (enzymology)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Papain (antagonists & inhibitors)</term><term>Papain (chemistry)</term><term>Papain (genetics)</term><term>Protein Structure, Tertiary</term><term>Sequence Alignment</term><term>Viral Proteins (antagonists & inhibitors)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Cristallographie aux rayons X</term><term>Domaine catalytique</term><term>Données de séquences moléculaires</term><term>Modèles moléculaires</term><term>Papaïne ()</term><term>Papaïne (antagonistes et inhibiteurs)</term><term>Papaïne (génétique)</term><term>Protéines virales ()</term><term>Protéines virales (antagonistes et inhibiteurs)</term><term>Protéines virales (génétique)</term><term>Structure tertiaire des protéines</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Papain</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Papaïne</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Papain</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Papain</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Papaïne</term><term>Protéines virales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Catalytic Domain</term><term>Crystallography, X-Ray</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Protein Structure, Tertiary</term><term>Sequence Alignment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cristallographie aux rayons X</term><term>Domaine catalytique</term><term>Données de séquences moléculaires</term><term>Modèles moléculaires</term><term>Papaïne</term><term>Protéines virales</term><term>Structure tertiaire des protéines</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0165">The 3D structure of the MERS-CoV papain-like protease (PL<sup>pro</sup>) has been determined.</p></list-item><list-item id="o0010"><label>•</label><p id="p0170">The enzyme has a deficient oxyanion hole and unique S3 as well as S5 subsites.</p></list-item><list-item id="o0015"><label>•</label><p id="p0175"><italic>In-vitro</italic> kinetics of the MERS-CoV PL<sup>pro</sup> are slower than for the SARS-CoV enzyme.</p></list-item><list-item id="o0020"><label>•</label><p id="p0180">Restoring the oxyanion hole through mutagenesis enhances the enzyme kinetics.</p></list-item><list-item id="o0025"><label>•</label><p id="p0185">The unique features of the enzyme will allow design of MERS-specific antivirals.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P. Wadhwani</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. Mesters</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A. McGeer</name></author><author><name sortKey="Perl, T M" uniqKey="Perl T">T.M. Perl</name></author><author><name sortKey="Price, C S" uniqKey="Price C">C.S. Price</name></author><author><name sortKey="Al Rabeeah, A A" uniqKey="Al Rabeeah A">A.A. Al Rabeeah</name></author><author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name></author><author><name sortKey="Alabdullatif, Z N" uniqKey="Alabdullatif Z">Z.N. 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Hilgenfeld</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Lei, Jian" sort="Lei, Jian" uniqKey="Lei J" first="Jian" last="Lei">Jian Lei</name></noRegion><name sortKey="Anemuller, Stefan" sort="Anemuller, Stefan" uniqKey="Anemuller S" first="Stefan" last="Anemüller">Stefan Anemüller</name><name sortKey="Anemuller, Stefan" sort="Anemuller, Stefan" uniqKey="Anemuller S" first="Stefan" last="Anemüller">Stefan Anemüller</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><name sortKey="Lei, Jian" sort="Lei, Jian" uniqKey="Lei J" first="Jian" last="Lei">Jian Lei</name><name sortKey="Ma, Qingjun" sort="Ma, Qingjun" uniqKey="Ma Q" first="Qingjun" last="Ma">Qingjun Ma</name><name sortKey="Ma, Qingjun" sort="Ma, Qingjun" uniqKey="Ma Q" first="Qingjun" last="Ma">Qingjun Ma</name><name sortKey="Mesters, Jeroen R" sort="Mesters, Jeroen R" uniqKey="Mesters J" first="Jeroen R." last="Mesters">Jeroen R. Mesters</name><name sortKey="Mesters, Jeroen R" sort="Mesters, Jeroen R" uniqKey="Mesters J" first="Jeroen R." last="Mesters">Jeroen R. Mesters</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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